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National Veterinary Services (NVS)

Antibiotic Action

While antibiotics have become an increasingly important part of veterinary medicine, it is important for the pet owner to understand that the use of antibiotics comes at a cost. The inability of antibiotics to avoid damaging the beneficial bacteria of the gut creates gastrointestinal problems for companion animals.

Disruption of Natural Intestinal Flora

A healthy digestive system results from an appropriate microflora balance in the stomach. Unfortunately, as we have already seen, antibiotics do not always select between good and bad bacteria

Disruption of Natural Intestinal Flora

Prebiotic

“A selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora, that confer benefits.” (Gibson 2004)

Probiotic

Probiotics are microorganisms such as bacteria or yeast that can be added to the food with the purpose of regulating the intestinal flora of the host (Parker 1974)

MANNAN-OLIGOSACCHARIDE (MOS) (Prebiotic)

  • MOS PreBiotic improves the intestinal flora, resulting in faster recovery from diarrhoea
  • It has a multi mode of action

Binds to pathogens

Prevents them adhering to the intestinal wall and so they are excreted

Stimulates Immune System

To produce protein which will bind pathogens – prevents them adhering to the intestinal wall and so they are excreted

Supports Healthy Flora

Provides a substrate to support growth of desirable microorganisms

MOS – Supports Healthy Flora

  • Enhance the growth of beneficial bacteria
  • Substrate for the growth of beneficial bacteria
  • Lactobacillus, bifidobacterial
  • MOS increased faecal bifidobacteria concentrations… MOS alter faecal microbial populations and certain indices of the immune system of senior dogs (C. Grieshop, 2010).

Probiotic – Enterococcus Faecium

  • An example of beneficial bacteria
  • Improves the microflora balance encouraging a healthy gastrointestinal tract
  • With increased levels of bacteria comes increased competition for adhesion sites and resources
  • This results in less pathogens attaching to the stomach and a higher death rate of pathogens due to the lack of essential resources

“Superbugs”

Antibiotic Resistance: happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow.

Digestive Health and Immune Health are One and the Same!

Antimicrobial stewardship is a set of coordinated measures designed to improve and measure the appropriate use of antimicrobials. It aims to reduce antibiotic resistance by limiting the use of broad spectrum antibiotics.

One way in which we can help is the boosting of our pet’s natural immune system.

MOS – Stimulates Immunity

  • Stimulates the liver to secrete mannose binding protein, Lectin
  • Lectin binds to pathogens, preventing their adhesion to the intestinal wall, and so they are excreted
    • e.g. E. coli, Salmonella, Pseudomonas

  • MOS has been shown to reduce faecal E. coli and C. perfringens and tended to promote greater concentrations of beneficial Lactobacilli and Bifidobacteria spp (P. Spring, 2015).

MOS - Binds

    • MOS binds to type-1 mannose site in the bacterium, preventing the latter from binding to glycoproteins of intestinal cells
    • “The action of MOS is to bind to type-1 mannose site in the bacterium, preventing the latter from binding to glycoproteins of intestinal cells.” (E.M.M.F. Gouveia, 2013).

E. Faecium – Immune Stimulator

E. Faecium – Immune Stimulator 2

Lethargy

One of the most visible side effects of antibiotic use is a lack of energy in Pets. This is usually a symptom of the infection being treated.

Combating Lethargy - Dextrose (D glucose)

  • Instant source of energy
  • Primary Source of Energy for Cells
  • Sole source of brain and red blood cell
  • Quickly accessible energy when digestive system is compromised or fatigue due to antibiotic treatment of infection

Nausea/Vomiting

  • Nausea and vomiting are a rare side effect of antibiotic treatment but may occur due to intolerance
  • Excess antibiotic and toxic metabolites can irritate the lining of the stomach and lead nausea and vomiting
  • Continued nausea and vomiting can lead to ulceration

Diosmectite – The Ultimate Enteroadsorbent

Binds

1 nm thick layers of alumina silicate sheets.

Powerful cation exchange potential. 

High adsorption of toxins, viruses, bacteria and water.

Capacity to swell to 4nm.

Protects

Integrates into the mucus layer.

Has a direct effect on the physical properties of the mucus. 

Has been proven to repair mucosal integrity.

Reduces

Frequency of both stools and vomiting due to its ability to bind and excrete the root cause

Loss of Appetite/ Antibiotic Induced Diarrhoea

The passing of certain medications such as antibiotics through the gastrointestinal tract can lead to a loss of appetite. A lack of absorption of essential nutrients can lead to further illness due to a weakened immune system.

Certain antibiotics can also induce diarrhoea. Diosmectite can successfully reduce the frequency of watery stools.

Malnutrition due to Antibiotic Induced Diarrhoea / Loss of Appetite

  • Glutamine è support mucosal integrity and facilitate absorption which enhances the absorpton of nutrients       
  • Electrolytes (K, Na, Cl) è alleviate losses, support recovery
  • Dextrose (D glucose) = easily absorbable source of energy for the body
  • Glycerine è a humectant, it attracts water assisting with dehydration associated with diarrhoea

Directions for Use

The paste can be added to the animal’s food or administered directly using the syringe.

Storage Instructions

Store in a cool, dry place. For animal use only. Keep out of reach of children.

Apply Orally
Apply to Food
Antibiotic Focus